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Clinical Nutrition ESPEN, 38, 4349

Still, excessive intake above 400 mcg a day from food and supplement sources combined -- can be problematic because it can lead to selenium toxicity, which can cause hair loss, gastrointestinal upset, and other health issues

The process of metformin exerting its extensive effects cannot be separated from the regulation of gut microbiota

Participants had established CVD (including prior heart attack, stroke, or peripheral arterial disease), chronic heart failure or CKD (stage III or higher) or were aged 60 or older with at least one CVD risk factor

I have no idea how this got proposed and why people thought this was a good idea, but incredible that it worked